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By Jackie Khor

21 April 2010

Coenzyme Q10 and Its Potential in anti-Hypertensive Therapy

Hypertension represents an increasing global burden of disease.  It is currently managed by the use of a variety of medications.  These medications are effective in reducing blood pressure, but many have undesirable side effects such as renal or cardiac dysfunction, cough and depression.  Coenzyme Q10 (CoQ10), also known as ubiquinone, is an antioxidant and an integral component of the mitochondrial respiratory chain for energy production.  It is found in all tissues and organs of the body but in highest concentration in the heart.  There is evidence of CoQ10 deficiency in hypertension, heart failure and in statin-treated hypercholesterolemic individuals.

To assess the overall efficacy of Coenzyme Q10 supplementation in the treatment of hypertension and the incidence of side effects, A meta-analysis was performed in 12 clinical trials (362 patients in total) comprising three randomized controlled trials, one crossover study and eight open label studies.  In most of the 12 clinical trials, a daily dosage of 100-120mg of Coenzyme Q10 was used for a period of 4-20 weeks.

All three types of study (randomized controlled, crossover and open label) showed decreases in systolic blood pressure ranging from 11 to 17mm Hg, and in diastolic blood pressure ranging from 8 to 10mm Hg, without significant side effects.

An increase in oxidative stress is well documented in hypertensive states.  In blood vessels, oxidative stress impairs the ability of endothelium to induce NO-mediated relaxation of underlying smooth muscle with resultant vasoconstriction and increased blood pressure.  The study author postulated that the primary action of CoQ10 in clinical hypertension is vasodilatation, via a direct effect on the endothelium and vascular smooth muscle.  CoQ10 may also have a particular therapeutic role in hypertensive patients with consistently increased levels of oxidative stress.

Source: Journal of Human Hypertension (2007) 21, 297–306

CoQ10 is an antioxidant that plays an essential role in the production of energy in heart cells, helping to maintain a healthy cardiovascular system. It is an essential nutrient for the basic functioning of cells. Our natural levels of CoQ10 decline as we age and with taking certain medications.

CoQuinone 100 supplement is formulated with a potent level to help you get an advanced level of CoQ10 in one tablet. It helps support healthy heart function, superior antioxidant protection and even helps reduce the oxidation of LDL cholesterol.

5 April 2010

You may be surprised Vitamin D deficiency is now recognized as a world-wide problem with health consequences even in a sunshine region.

The major cause of vitamin D deficiency is the lack of appreciation that sun exposure in moderation is the major source of vitamin D for most humans. Increased skin pigmentation markedly reduces vitamin D synthesis.

Inadequate dietary intake, winter season, latitude, aging, medication and certain medical condition are also associated with increased risk of vitamin D deficiency.

In Australia, a dramatic increase in skin cancer rates resulted in the promotion of sun-safe policy to avoid exposing the skin to direct sunlight without sun protection, i.e., clothing or sunscreen.

This message has resulted in a marked increase in the risk of vitamin deficiency in Australia. Studies suggest that upwards of 30–50% of children and adults world wide are at risk of vitamin D deficiency.

Very few foods naturally contain vitamin D, which is found in small quantities in foods such as fatty fish, Liver, and eggs. Foods that are fortified with vitamin D are often inadequate to satisfy either a child’s or an adult’s vitamin D requirement.

Vitamin D deficiency and Health Consequences:

Vitamin D deficiency can have musculoskeletal and nonskeletal consequences.

* It causes growth retardation and rickets in children and will precipitate and exacerbate osteopenia, osteoporosis, and fractures in adults
* It has been associated with proximal muscle weakness, increase in body sway, and an increased risk of falling
* It has been associated with increased risk of common cancers, autoimmune diseases, hypertension, and infectious diseases

Mild vitamin D deficiency is defined as serum 25-OHD levels in the range 25–50 nmol/L
Moderate vitamin D deficiency is defined as serum 25-OHD levels of 12.5–25 nmol/L
Severe vitamin D deficiency is defined as Serum 25-OHD levels of < 12.5 nmol/L.

A circulating level of 25-hydroxyvitamin D of >75 nmol/L, or 30 ng/mL, is required to maximize vitamin D’s beneficial effects for health. In the absence of adequate sun exposure, at least 800–1000 IU vitamin D3/day may be needed to achieve this level in children and adults. To treat moderate to severe vitamin D deficiency, supplementation with 3000-5000 IU/day for 6–12 weeks is often recommended.

Source: Am J Clin Nutr 2008;87(suppl):1080S– 6S. MJA 2005; 182 (6):281-285

5 April 2010

To date, clinical trials have not shown significant benefit of vitamin C supplementation in reducing stroke risk, but they have not examined the relation between plasma vitamin C concentrations and stroke risk in a general population.

A recent study published in the American Journal of Clinical Nutrition examined the relation between baseline plasma vitamin C concentrations and risk of incident stroke in a British population of over 20,000 adult men and women. The participants completed a health questionnaire and attended a clinic during 1993″1997. After an average follow-up time of 9.5 years, the participants in the top fourth of plasma vitamin C levels had a 42% lower risk of stroke compared to those with the lowest levels. These results were independent of age, sex, smoking, BMI, blood pressure, cholesterol, physical activity, diabetes, social class, alcohol consumption, and any supplement use.

Plasma vitamin C concentrations, therefore, may act as an indicator of lifestyle or other factors associated with reduced stroke risk and may be helpful in determining those at high risk of stroke.

American Journal of Clinical Nutrition, Vol. 87, No. 1, 64-69, January 2008

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