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Glucosamine HCl exhibits Anti-inflammatory Activity

Glucosamine (GS) is an amino monosaccharide and has been widely used as an alternative regimen for rheumatoid arthritis or osteoarthritis.  It has been suggested that GS exerts anti-inflammatory effect.  A recent study investigated the mechanism by which GS affects expression and activity of COX-2.

COX-2 (Cyclooxygenase-2) and its products, including PGE2, are involved in many inflammatory illnesses. NSAIDs that target COX-2 lessen major inflammatory symptoms such as fever and pain suggests COX-2’s role in inflammation. Thus, any compound that inhibits COX-2 has the potential to be clinically useful against inflammatory diseases.

In an in-vitro study, researchers evaluated the effects of different glucosamine salts (GS-HCl, GS sulfate) or a GS derivative (N-acetyl GS) and galactosamine HCl (Gal-HCl), on the expression of COX-2 and production of PGE2 in human cells.  The study found that, among GS salts or derivative tested, Glucosamien HCl specifically inhibits endogenous and cytokine-driven COX-2 expression at protein level via a mechanism associated with the down-regulation of COX-2 N-glycosylation and turnover.

The findings presented in this study may provide a potential explanation for the clinical effect of glucosamine supplements, particularly glucosamine HCl supplement, which are purported to have an anti-inflammatory activity.

Byeong-Churl Jang et al; Journal Of Biological Chemistry (2007); VOL 282(38):27622–27632

One Response

  1. Good Post! It is ndeeed by each one of us to stand up and protest against the health concerned crisis.

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