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CoQ10 Supplementation Benefit Patients with Heart Disease

The latest meta-analysis of clinical studies suggested that CoQ10 supplementation improves outcomes in patients with congestive heart failure (CHF).

CoQ10 (ubiquinone) is an antioxidant that plays two important biological roles.  It is an integral component of the mitochondrial respiratory chain used for ATP production; it is also a lipid-soluble antioxidant that slows lipid peroxidation in the circulation.  CoQ10 has been used to help improve functional status during CHF. Several clinical trials have examined the effects of CoQ10 on CHF, but some of the research has been inconclusive.

In a recently published paper in the American Journal of Clinical Nutrition, researchers conducted a meta-analysis to evaluate the effect of CoQ10 supplementation on ejection fraction (EF) and functional improvements of patients with CHF.

A systematic review of the research literature was performed using databases that included Medline, Embase, Cochrane Central Register of Controlled Trials, and examination of references from other selected studies. Included studies were randomized controlled trials of CoQ10 supplementation that reported EF or specific functional improvements as a primary outcome.

When all studies were pooled, supplementation with CoQ10 resulted in a net change of 3.67% in the EF and a trend in functional improvements. Cross-over studies of 12 weeks or more, daily dosages of at least 100 mg CoQ10, and patients with less severe CHF showed the most significant improvements in EF and health outcomes.

This meta-analysis of randomized controlled trials suggests that CoQ10 supplementation may improve the EF of patients with CHF.  However additional well-designed larger studies with a more diverse population are needed to exam if CoQ10 can be used as adjunct treatment with the standard therapy for CHF and its dose-response effect on stages of CHF.

Source: Fotino AD, Thompson-Paul AM, Bazzano LA. Am J Clin Nutr 2013 Feb;97(2):268-75.

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