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CoQ10 Supplementation May Benefits Patients with Congestive Heart Failure.

A recent meta-analysis of randomized controlled trials suggests that CoQ10 supplementation may improve the ejection fraction of patients with congestive heart failure.

CoQ10 (ubiquinone) is an antioxidant that has been used to help improve functional status during congestive heart failure (CHF). Several clinical trials have examined the effects of CoQ10 on CHF, but some of the research has been inconclusive.

In a recently published paper in the American Journal of Clinical Nutrition, researchers conducted a meta-analysis to evaluate the effect of CoQ10 supplementation on ejection fraction (EF) and functional improvements of patients with CHF.

A systematic review of the research literature was performed using databases that included Medline, Embase, Cochrane Central Register of Controlled Trials, and examination of references from other selected studies. Included studies were randomized controlled trials of CoQ10 supplementation that reported EF or specific functional improvements as a primary outcome.

When all studies were pooled, supplementation with CoQ10 resulted in a net change of 3.67% in the EF and a trend in functional improvements. Cross-over studies of 12 weeks or more, daily dosages of at least 100 mg CoQ10, and patients with less severe CHF showed the most significant improvements in EF and health outcomes.

This meta-analysis of randomized controlled trials suggests that CoQ10 supplementation may improve the EF of patients with CHF. However additional well-designed studies with a more diverse population are needed.

Source:
Fotino AD, Thompson-Paul AM, Bazzano LA. Am J Clin Nutr 2013 Feb;97(2):268-75.

One Response

  1. Ann Shirley




    Coenzyme q10 offers a number of health benefits that can help those suffering from congestive heart failure. One of the most important benefits is it can lower your cholesterol levels. Many people take statins for this purpose, but the coenzyme q10 supplements are a much safer option. In addition, the coenzyme q10 supplement also increases energy levels and reduces muscle aches and pains making it easier for you to work out for longer periods of time. More exercise makes for a healthier heart!

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