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Probiotic-containing yogurt improves the efficacy of quadruple therapy in eradicating Helicobacter pylori infection.

Helicobacter pylori is a bacterium that lives in the inner lining of the stomach, and causes damages to the lining of the stomach.  The infection can persist for many years.  Quadruple therapy is often used  as rescue regimen to eradicate primary H. pylori infection after triple therapy failure and antibiotic resistance.
One clinical study investigated the effects of prior treatment with Lactobacillus- and Bifidobacterium-containing yogurt (AB-Yogurt), and whether it can improve the efficacy of quadruple therapy in eradicating residual H. pylori after failed triple therapy.
One hundred thirty-eight patients in whom triple therapy failed were enrolled for a culture study of H. pylori to assess antimicrobial resistance. These patients were then randomly assigned in equal numbers to either a yogurt-plus-quadruple therapy group or a quadruple therapy-only group.  The patients received 1 wk of quadruple therapy with or without a 4-wk pretreatment with AB-yogurt (400 mL/d).  For both groups, test was conducted 6-wks after the quadruple therapy to assess the outcome of residual H. pylori eradication.
For the patients in the yogurt-plus-quadruple therapy group infected with either antibiotic-sensitive or -resistant H. pylori, the test value were significantly decreased after the 4-wk ingestion of AB-yogurt. The yogurt-plus-quadruple therapy group had a higher H. pylori eradication rate than did the quadruple therapy-only group.

This study suggests that a 4-wk pretreatment with Lactobacillus- and Bifidobacterium-contaning yogurt can decrease H. pylori loads despite antimicrobial resistance, thus improving the efficacy of quadruple therapy in eradicating residual H. pylori.

Source: Am J Clin Nutr 2006;83:864 –9.

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