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Turmeric (Increased Absorption with Meriva Bioavailable Curcumin)

01 October 2011

Curcuma longa (turmeric) has a long traditional use as a treatment for inflammatory conditions.  Curcumin are believe to contribute to the therapeutic benefits of turmeric extract with three curcuminoids as the main constituents. Numerous clinical trials have investigated the mechanisms and therapeutic potential of curcumin

Curcumin has a high instability at physiological pH and an inherently low intestinal absorption.  It is therefore very poorly bioavailable. Because of curcumin’s rapid plasma clearance, its therapeutic usefulness has been somewhat limited, leading researchers to investigate the benefits of complexing curcumin with other substances to increase systemic bioavailability.

In a randomized, double-blind, crossover human study, researchers at USANA Health Sciences, in conjunction with Università del Piemonte Orientale and Indena SPA in Italy, investigated the absorption rate of a unique extract of turmeric – the Meriva Bioavailable Curcumin. Eight healthy people took either a high or low dose Meriva Curcumin, or a reference placebo.  Their serum levels of the three major curcuminoids were then evaluated.

The study found that the total curcuminoid absorption was about 29-fold higher for Meriva curcumin (high or low) than for the unformulated curcuminoid mixture.  The improved absorption, and possibly also a better plasma curcuminoid profile, might underlie the clinical efficacy of Meriva curcumin at doses significantly lower than unformulated curcuminoid mixtures.

The Meriva curcumin extract used in this clinical trial is a special patented combination of curcumin with soybean-derived lecithin, produced and distributed by Indena SpA of Milan, Italy, the world’s largest manufacturer of standardized botanical extracts.

Source:
Cuomo J et al; J Nat Prod. 2011 Apr 25; 74(4):664-9

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